editorial features

Radek Špíšek, PhD

CEO and founding scientist, Sotio

“We have a very elegant way and very sophisticated way to induce a complex, broad immune response that targets multiple targets on the tumor cell.”

Brian Culley

CEO, Lineage Cell Therapeutics

“I think there is going to be explosive growth in the field of cell therapy.”

Matt Stober

president and CEO, Istari Oncology

“Our mission is to harness the patient’s own immune system to target and sustain the lethal response to cancer.”

Paul Garofolo

CEO, Locus Biosciences

“Wherever you know the bug that you need to get out of the body to have a therapeutic effect, we’ve got the world’s most powerful tool to remove that bug.”

Caroline Smith-Moore, PhD

assistant director Analytical, NC state’s Biomanufacturing Training and Education Center

“The hands-on portion of these courses is so important.”

John Proctor, PhD

senior vice president of antibody therapeutics, Berkeley Lights

“The company is focused on allowing scientists to thoroughly investigate functional phenotypes that will lead to very effective and efficacious cell therapies.”

Sue Washer

CEO, AGTC

“We are trying to make a difference for patients with inherited retinal diseases and who are losing visual function every day and whose quality of life is severely affected and where there is not much else available for them.”

Pieter Rottiers, PhD

CEO, Precigen ActoBio

“We were one of the first to approach regulators from both sides of the Atlantic — the FDA as well as several European authorities — with a new concept: a live, genetically modified bacteria to be used for human purposes.”

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videos interviews

 

About the BioTools Innovator competition

Experiences of being a woman in science and business

Making the transition from a postdoc to industry job

Long-term career planning for PhDs

Insights into launching a science startup

The importance of mentorship

Strategies to be an effective mentor

Event Coverage

Nobel Prize winner Doudna shares perspectives on future of CRISPR gene editing

2021 ASGCT Annual Meeting

Potential of gene editing for clinical use highlighted at ASGCT 2021

2021 ASGCT Annual Meeting

Single-cell technologies bring new insights to tumor cells

AACR 2021 Annual Meeting

Beyond capital — what it takes for biopharma startups to succeed

Biotech Showcase 2021

Is ‘bespoke’ therapy the future of genomic medicine?

ASGCT Policy Summit 2020

From DNA to precision medicine, researchers discuss breakthroughs in cancer research

AACR 2020 Annual Meeting

Optofluidics aids cell line development for antibody-based therapies

Bioprocess International Digital Weeks 2020

3 reasons the coronavirus outbreak has been so severe

Congressional Biomedical Research Caucus Briefing

Research News

How one mammalian DNA polymerase challenges the central dogma of biology

June 14, 2021 — New research demonstrates how an unusual mammalian DNA polymerase, called polymerase θ (Polθ), can facilitate the conversion of RNA into DNA — the opposite of normal polymerase function. The data, published in Science Advances on June 11, could challenge the central dogma of molecular biology that states that DNA makes RNA, which in turn makes proteins.

A new way to account for evolution in engineered biological systems

June 9, 2021 — A defining characteristic of biology is that life evolves. Traditional biological engineering views an engineered product as a final destination in the design process. However, the authors of a perspective piece published in Nature Communications on June 7 believe that a new perspective is needed for engineering of biological systems — one that takes into consideration how a biosystem will continue to evolve over time.

 

Survey: Scientists want to boost use of lab automation

May 25, 2021 — In the era of big data and new analytical technologies, research laboratories are rapidly adopting new lab automation equipment and processes. While most labs are already using some type of automation in their workflows, many researchers would like to increase their use of these new technologies, according to results from a new ScienceBoard.net survey.

Prime editing creates desired gene mutations without collateral damage

March 30, 2021 — A new gene editing tool called prime editing was demonstrated to efficiently create cell-specific knockout mice compared to traditional gene editing techniques. While both platforms successfully created mutations, prime editing did so without measurable on-target indels or off-targeting events, according to a study published in Genome Biology on March 16.

Scientists uncover secrets to controlling gene expression

March 19, 2021 — Bioengineers have demonstrated that simultaneous control over transcription and translation in cells can achieve the most stringent control of gene expression to date. The findings, published in Nature Communications on March 19, will open new avenues for improved biotechnologies and synthetic biology applications.

Not all genome editing tools are equal: CRISPR vs. TALEN

January 27, 2021 — In recent years, a number of novel genome editing tools have emerged, although not all of these tools are equal in terms of efficiency and accuracy, according to a new study published in Nature Communications on January 27. The study observed different DNA search proteins to identify the specific ways that they find target sequences in the genome.

Researchers investigate how a potent mAb blocks SARS-CoV-2

May 4, 2020 — Based on previous research that explored therapies against SARS-CoV, a new report has identified a fully human monoclonal antibody (mAb) that prevents the SARS-CoV-2 virus from infecting cultured cells. Authored by a team of researchers from Utrecht University, Erasmus Medical Center, and Harbour BioMed, the report was published in Nature Communications on May 4.

New antiviral drug could work against many viruses, including SARS-CoV-2

April 10, 2020 — An antiviral drug called EIDD-2801 that’s in preclinical testing has potential to be developed into the silver bullet that medical professionals seek to treat COVID-19, according to new research published in Science Translational Medicine on April 6.

COVID-19 shuts down research labs as concern grows among scientists

April 7, 2020 — Almost half of all scientific research labs that participated in a recent survey were shut down due to concerns about the COVID-19 outbreak. Survey results indicate that scientists are quite concerned and that their work is considerably impacted by the pandemic, according to a new COVID-19 scientist sentiment tracker.

Enrichment NGS emerges as surveillance tool for coronavirus

January 29, 2020 — As coronavirus continues to grow as a global health concern, researchers urgently seek efficient methods to predict and mitigate emerging coronavirus strains. An international team of researchers believes that targeted next-generation sequencing (NGS) may be a valuable tool for monitoring both current and future outbreaks of coronavirus. The research was published in mSphere on January 29.

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Samantha Black, PhD

Arlington, Virginia 

22204

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